You are warned that if you imbibe Nectar, it will surely kill you.
So, should you throw caution to the wind and do it anyway?
Should you imbibe Nectar in Shadow Of The Erdtree?

Yes, you should imbibe Nectar in Elden Ring.
Nothing happens if you only imbibe the Nectar once, twice, or three times.
Thiollier will react with anger, thinking that you’re lying to him.

you’re able to then reload the area and speak to Thiollier once more.
He still won’t believe you but he’ll be less adamant than before.
You may also recieveAnsbachas a summon option depending on your choices duringLeda’s questline.
What happens if you don’t imbibe the Nectar?
If you choose not to imbibe St. Trina’s Nectar, nothing good happens.
In fact,nothing happens at all.
You are free to return and imbibe the Nectar later on if you change your mind.