Using the Eldritch Rune is the only way to unlock it.

Don’t worry if you don’t succeed though, because it doesn’t unlock any further options.

However, you could simply approach and play through the scenario again.

A screenshot from Larian Studios' Baldur’s Gate 3 showing party member Shadowheart

If you decide to make the Illithid Wisdom check, you must exceed a measly minimum of 2.

That wraps up everything it’s crucial that you know to save Shadowheart in Baldur’s Gate 3.

Former contributor Emily Gera also works on it.

Baldur’s Gate 3 image showing a player looking in the inventory of a corpse, hovering over an Eldritch Rune.